Abstract Description

There is a great need for low-cost intelligent biochips capable of massive parallel detection to be used in portable instrumentation. Electrochemical methods are inherently low-cost, miniaturisable and easily integrated into multiplexed systems for the parallel screening of panels of biomarkers. Of particular interest are biologically sensitive field-effect transistors (BioFETs) and impedance-based sensors. We will exemplify the use of synthetic molecules such as DNA aptamers and peptide aptamers, as alternatives to antibodies, as well as oligonucleotide-based approaches in impedance and BioFET sensors for the detection of a range of biomarkers in medical diagnosis and for water/wastewater monitoring. We will also exemplify the use of integration processes to create fully functional Lab-on-Chip biodevices.